The importance of renal biopsy in the management of renal transplantation.

Renal biopsy remains the "gold standard" for the diagnosis of renal allograft dysfunction. The aim of our study was to highlight the importance of renal biopsy in the management of allograft dysfunction (early diagnosis and therapeutic approach). Our study included 23 renal allograft biopsies from 20 patients. This retrospective study analyzed the demographic and clinical data, histological results and the evolution of renal function under the immunosuppressive regimens. Conclusions: The most frequently encountered histopathological patterns were humoral rejection, interstitial fibrosis and chronic cellular rejection. Patients under continuous treatment with cyclosporine developed chronic cellular reject more frequently; on the opposite, patients under continuous treatment with tacrolimus developed chronic humoral reject more frequently.